Dental Pulp Engineering, Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics
Dental pulp engineering indicate that regenerative treatment strategies in endodontics are feasible. Clinically, revascularization procedures render completion of root formation in immature teeth. The generation of a pulp-like tissue after seeding of dental pulp stem cells into dentin discs or cylinders and transplantation in vivo is possible in this experimental setup.
Conclusions: Dentin conditioning considerably influences DPSC fate when seeded in close proximity to dentin. This information might be critical for optimized strategic planning for future regenerative endodontic treatment. (Source: Journal of Endodontics)